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When liver cells can no longer handle the excess Cu + through increased excretion via CTR1 and metallothionein synthesis, the Cu + is stored in lysosomes

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Waśkiel‐Burnat A., Osińska M., Salińska A., et al., “The Role of Serum Th1, Th2, and Th17 Cytokines in Patients With Alopecia Areata: Clinical Implications,” Cells 10, no